Evan Feinberg, PhD

Assistant Professor
M_Anatomy

My lab (www.evanfeinberglab.com) aims to understand how sensory input is represented in the brain and transformed into behavioral commands. We study this problem in the superior colliculus (SC), a structure comprising functionally diverse sensory and motor neurons interleaved with fibers from myriad cortical and subcortical areas. This remarkable neuroanatomy poises the SC as an integrative hub, but has also hindered efforts to dissect SC circuitry using classical methods, such as lesions, that offer poor spatial and temporal resolution. In order to record from and manipulate genetically defined cell types, we study the mouse SC, where we capitalize on an experimental preparation I developed that allows two-photon imaging of neuronal population activity in the SC of awake animals. We apply these methods to decipher computations in the context of quantitative behavioral assays. Our long-term goal is to understand how the brain encodes information from input to output.

Publications: 

Soma-Targeted Imaging of Neural Circuits by Ribosome Tethering.

Neuron

Chen Y, Jang H, Spratt PWE, Kosar S, Taylor DE, Essner RA, Bai L, Leib DE, Kuo TW, Lin YC, Patel M, Subkhangulova A, Kato S, Feinberg EH, Bender KJ, Knight ZA, Garrison JL

New technologies for imaging synaptic partners.

Current opinion in neurobiology

Wickersham IR, Feinberg EH

A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans.

Nature

Macosko EZ, Pokala N, Feinberg EH, Chalasani SH, Butcher RA, Clardy J, Bargmann CI

GFP Reconstitution Across Synaptic Partners (GRASP) defines cell contacts and synapses in living nervous systems.

Neuron

Feinberg EH, Vanhoven MK, Bendesky A, Wang G, Fetter RD, Shen K, Bargmann CI

Caenorhabditis elegans SID-2 is required for environmental RNA interference.

Proceedings of the National Academy of Sciences of the United States of America

Winston WM, Sutherlin M, Wright AJ, Feinberg EH, Hunter CP

Global 'worming'.

Genome biology

Chalasani SH, Feinberg EH, Hilliard MA

Systemic RNAi in Caenorhabditis elegans.

Cold Spring Harbor symposia on quantitative biology

Hunter CP, Winston WM, Molodowitch C, Feinberg EH, Shih J, Sutherlin M, Wright AJ, Fitzgerald MC

Analysis of mouse embryonic patterning and morphogenesis by forward genetics.

Proceedings of the National Academy of Sciences of the United States of America

García-García MJ, Eggenschwiler JT, Caspary T, Alcorn HL, Wyler MR, Huangfu D, Rakeman AS, Lee JD, Feinberg EH, Timmer JR, Anderson KV

Transport of dsRNA into cells by the transmembrane protein SID-1.

Science (New York, N.Y.)

Feinberg EH, Hunter CP