Leadership

Michael Brainard, Ph.D.

Director

[email protected]

 

Christoph Schreiner, MD, PhD

Central auditory stations
Otolaryngology

Christoph E. Schreiner, MD, PhD, is Professor in the Departments of Otolaryngology – Head and Neck Surgery (OHNS), and Bioengineering&Therapeutic Sciences at the University of California, San Francisco. He received his master degree and PhD degree, both in physics, from the University of Göttingen, Germany. Dr. Schreiner completed a medical degree from the University of Göttingen, and the Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany, followed by a neuroscience research fellowship at UCSF.

Dr. Schreiner’s research focuses on understanding of the functional organization of central auditory stations of the mammalian brain. He is mainly interested in the role of the auditory forebrain (medial geniculate body and auditory cortex) in the encoding of complex auditory signals - such as speech and communication signals - in normal and hearing-impaired models. By combining physiological, neuroanatomical, and computational approaches, Dr. Schreiner and his colleagues attempt to provide a better understanding of the cortical processing of complex sounds and its contribution to sound perception.

Dr. Schreiner is a member of the Association for Research in Otolaryngology, the Society for Neuroscience, the American Physiological Society, and the Acoustical Society of America. He has published over 150 reviewed articles, and he has also contributed to over 50 book chapters.

Specialty:
Basic and translational neuroscience research

Expertise:
Central auditory nervous processing of sounds

Professional Interests:
Physiology of the mammalian central auditory system, cortical plasticity, speech and communication, neuroanatomical foundation of auditory forebrain, hearing loss and tinnitus, dyslexia, physiological substrates of auditory perception, computational neuroscience of audition

Education and Training:
• PhD: University of Göttingen, Germany
• Medical School: University Göttingen, Germany
• Post-doctoral Fellowship: University of California, San Francisco

Awards and Honors:
• 2000 Research and Development Council of New Jersey - Thomas Alva Edison Patent Award

Publications: 

Receptive-field nonlinearities in primary auditory cortex: a comparative perspective.

Homma NY, See JZ, Atencio CA, Hu C, Downer JD, Beitel RE, Cheung SW, Najafabadi MS, Olsen T, Bigelow J, Hasenstaub AR, Malone BJ, Schreiner CE

Auditory training remodels hippocampus-related memory in adult rats.

Jia G, Sun Y, An P, Wu W, Shen Y, Liu H, Shan Y, Wang J, Lai CSW, Schreiner CE, He H, Zhou X

Auditory Cortical Plasticity Dependent on Environmental Noise Statistics.

Homma NY, Hullett PW, Atencio CA, Schreiner CE

Dlx1 and Dlx2 Promote Interneuron GABA Synthesis, Synaptogenesis, and Dendritogenesis.

Pla R, Stanco A, Howard MA, Rubin AN, Vogt D, Mortimer N, Cobos I, Potter GB, Lindtner S, Price JD, Nord AS, Visel A, Schreiner CE, Baraban SC, Rowitch DH, Rubenstein JLR

A Critical Role of Inhibition in Temporal Processing Maturation in the Primary Auditory Cortex.

Cai D, Han R, Liu M, Xie F, You L, Zheng Y, Zhao L, Yao J, Wang Y, Yue Y, Schreiner CE, Yuan K

Anisomorphic cortical reorganization in asymmetric sensorineural hearing loss.

Cheung SW, Atencio CA, Levy ERJ, Froemke RC, Schreiner CE

Effects of Signal-to-Noise Ratio on Auditory Cortical Frequency Processing.

Teschner MJ, Seybold BA, Malone BJ, Hüning J, Schreiner CE

Inhibitory Actions Unified by Network Integration.

Seybold BA, Phillips EAK, Schreiner CE, Hasenstaub AR

Strategies for optical control and simultaneous electrical readout of extended cortical circuits.

Ledochowitsch P, Yazdan-Shahmorad A, Bouchard KE, Diaz-Botia C, Hanson TL, He JW, Seybold BA, Olivero E, Phillips EA, Blanche TJ, Schreiner CE, Hasenstaub A, Chang EF, Sabes PN, Maharbiz MM

Modulation-frequency-specific adaptation in awake auditory cortex.

Malone BJ, Beitel RE, Vollmer M, Heiser MA, Schreiner CE

Perceptual Training Restores Impaired Cortical Temporal Processing Due to Lead Exposure.

Zhu X, Liu X, Wei F, Wang F, Merzenich MM, Schreiner CE, Sun X, Zhou X

Spectral context affects temporal processing in awake auditory cortex.

Malone BJ, Beitel RE, Vollmer M, Heiser MA, Schreiner CE

Long-term modification of cortical synapses improves sensory perception.

Froemke RC, Carcea I, Barker AJ, Yuan K, Seybold BA, Martins AR, Zaika N, Bernstein H, Wachs M, Levis PA, Polley DB, Merzenich MM, Schreiner CE

Chronic reduction in inhibition reduces receptive field size in mouse auditory cortex.

Seybold BA, Stanco A, Cho KK, Potter GB, Kim C, Sohal VS, Rubenstein JL, Schreiner CE

Hierarchical representations in the auditory cortex.

Sharpee TO, Atencio CA, Schreiner CE

A tribute to Jeffery A. Winer.

Schreiner CE, Cant NB

Distinct core thalamocortical pathways to central and dorsal primary auditory cortex.

Read HL, Nauen DW, Escabí MA, Miller LM, Schreiner CE, Winer JA

Encoding of temporal information by timing, rate, and place in cat auditory cortex.

Imaizumi K, Priebe NJ, Sharpee TO, Cheung SW, Schreiner CE

Developmental sensory experience balances cortical excitation and inhibition.

Dorrn AL, Yuan K, Barker AJ, Schreiner CE, Froemke RC

Realignment of interaural cortical maps in asymmetric hearing loss.

Cheung SW, Bonham BH, Schreiner CE, Godey B, Copenhaver DA

Cooperative nonlinearities in auditory cortical neurons.

Atencio CA, Sharpee TO, Schreiner CE

Two thalamic pathways to primary auditory cortex.

Read HL, Miller LM, Schreiner CE, Winer JA

Spectral integration plasticity in cat auditory cortex induced by perceptual training.

Keeling MD, Calhoun BM, Krüger K, Polley DB, Schreiner CE

Frequency-modulation encoding in the primary auditory cortex of the awake owl monkey.

Atencio CA, Blake DT, Strata F, Cheung SW, Merzenich MM, Schreiner CE

Unbalanced synaptic inhibition can create intensity-tuned auditory cortex neurons.

Tan AY, Atencio CA, Polley DB, Merzenich MM, Schreiner CE

Development of spectral and temporal response selectivity in the auditory cortex.

Chang EF, Bao S, Imaizumi K, Schreiner CE, Merzenich MM

Fine functional organization of auditory cortex revealed by Fourier optical imaging.

Kalatsky VA, Polley DB, Merzenich MM, Schreiner CE, Stryker MP

Auditory thalamocortical transformation: structure and function.

Winer JA, Miller LM, Lee CC, Schreiner CE

Plasticity in primary auditory cortex of monkeys with altered vocal production.

Cheung SW, Nagarajan SS, Schreiner CE, Bedenbaugh PH, Wong A

Concurrent tonotopic processing streams in auditory cortex.

Lee CC, Imaizumi K, Schreiner CE, Winer JA

Neural processing of amplitude-modulated sounds.

Joris PX, Schreiner CE, Rees A

Modular functional organization of cat anterior auditory field.

Imaizumi K, Priebe NJ, Crum PA, Bedenbaugh PH, Cheung SW, Schreiner CE

Identification of a monogenic locus (jams1) causing juvenile audiogenic seizures in mice.

Misawa H, Sherr EH, Lee DJ, Chetkovich DM, Tan A, Schreiner CE, Bredt DS

Functional architecture of auditory cortex.

Read HL, Winer JA, Schreiner CE

Representation of spectral and temporal envelope of twitter vocalizations in common marmoset primary auditory cortex.

Nagarajan SS, Cheung SW, Bedenbaugh P, Beitel RE, Schreiner CE, Merzenich MM

Toxicity evaluation of petroleum blending streams: inhalation subchronic toxicity/neurotoxicity study of a light catalytic cracked naphtha distillate in rats.

Lapin C, Bui Q, Breglia R, Koschier F, Podhasky P, Lapadula E, Roth R, Schreiner C, White R, Clark C, Mandella R, Hoffman G

Sensory input directs spatial and temporal plasticity in primary auditory cortex.

Kilgard MP, Pandya PK, Vazquez J, Gehi A, Schreiner CE, Merzenich MM

Auditory cortical neuron response differences under isoflurane versus pentobarbital anesthesia.

Cheung SW, Nagarajan SS, Bedenbaugh PH, Schreiner CE, Wang X, Wong A

Organization of inhibitory frequency receptive fields in cat primary auditory cortex.

Sutter ML, Schreiner CE, McLean M, O'connor KN, Loftus WC

Speech modifications algorithms used for training language learning-impaired children.

Nagarajan SS, Wang X, Merzenich MM, Schreiner CE, Johnston P, Jenkins WM, Miller S, Tallal P

Sound-induced seizures in serotonin 5-HT2c receptor mutant mice.

Brennan TJ, Seeley WW, Kilgard M, Schreiner CE, Tecott LH

Temporal processing in cat primary auditory cortex.

Schreiner CE, Mendelson J, Raggio MW, Brosch M, Krueger K

Language comprehension in language-learning impaired children improved with acoustically modified speech.

Tallal P, Miller SL, Bedi G, Byma G, Wang X, Nagarajan SS, Schreiner C, Jenkins WM, Merzenich MM

Temporal processing deficits of language-learning impaired children ameliorated by training.

Merzenich MM, Jenkins WM, Johnston P, Schreiner C, Miller SL, Tallal P

Neural mechanisms of tinnitus.

Lenarz T, Schreiner C, Snyder RL, Ernst A

Tinnitus suppression by cochlear implants.

McKerrow WS, Schreiner CE, Snyder RL, Merzenich MM, Toner JG